Overview
MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA Type-C) is a synthetic 16-amino-acid peptide, sold here as a lyophilized powder vial. It's encoded within the mitochondrial genome rather than nuclear DNA — one of a small class of "mitochondrial-derived peptides" — and has become a frequently studied compound in the preclinical metabolic-regulation literature.
Chemical identifiers
| Full name | Mitochondrial Open Reading Frame of the 12S rRNA Type-C (MOTS-c) |
| Category | Synthetic mitochondrial-derived peptide (16-mer) |
| CAS number | 1627580-64-6 |
| Molecular formula | C101H152N28O22S2 |
| Molar mass | 2174.64 g/mol |
| Sequence | Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg (MRWQEMGYIFYPRKLR) |
Source: PubChem CID 146675088.
Molecular structure
Source: PubChem CID 146675088.
Studied in the research literature for
General topic areas this compound appears in published preclinical/animal research — not a statement of confirmed outcomes, and not applicable to human use.
- Preclinical models of metabolic regulation and insulin sensitivity
- Mitochondrial-derived peptide and cellular stress-response signaling studies
- Exercise-response and AMPK pathway research
- Age-related metabolic decline models
Storage & handling
- Store lyophilized (powder) vials at -20°C, protected from light.
- Once reconstituted for laboratory use, keep refrigerated at 2–8°C.
- Avoid repeated freeze-thaw cycles, which can degrade peptide integrity.
- Handle in accordance with your institution's standard laboratory safety practices.
Related
View this product in the catalog · View Certificate of Analysis
Research use only. This page is provided for laboratory research reference purposes only. It does not constitute medical advice, and nothing on this page should be interpreted as guidance for human or animal use. Products are not evaluated for safety or efficacy in humans.
